Approximately 1% of the population lacks the ability to digest fungal cell walls due to the composition of their microbiomes. Mushrooms do not “sit well” with them, and a full dose of psilocybin mushrooms would bring digestive distress that would detract from their experience.
You have other options! There are psychedelic medicines (e.g., 4-AcO-DMT), that are structurally similar to psilocybin mushrooms but allow you to avoid some of the unpleasant side effects such as nausea and digestive distress.
A trained psychedelic therapist or guide will be able to help you navigate your options with psychedelic medicine, including the right choice for your body. They should be asking you about your experience with mushrooms in general and your digestion to ensure that you have the safest and most gentle experience possible. (But if they don’t, speak up! There are many ways to assist you.)
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